ParkinsonCanadaV1, Main, Exploration, bibRecord, 000C80

Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins

Identifieur interne : 000C80 ( Main/Exploration ); précédent : 000C79; suivant : 000C81

Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins

Auteurs : Dusan Zencak [Suisse] ; Karine Schouwey [Suisse] ; Danian Chen [Canada] ; Per Ekström [Suède] ; Ellen Tanger [Pays-Bas] ; Rod Bremner [Canada] ; Maarten Van Lohuizen [Pays-Bas] ; Yvan Arsenijevic [Suisse]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2013.

RBID : PMC:3574927

Abstract

The epigenetic regulator Bmi1 controls proliferation in many organs. Reexpression of cell cycle proteins such as cyclin-dependent kinases (CDKs) is a hallmark of neuronal apoptosis in neurodegenerative diseases. Here we address the potential role of Bmi1 as a key regulator of cell cycle proteins during neuronal apoptosis. We show that several cell cycle proteins are expressed in different models of retinal degeneration and required in the Rd1 photoreceptor death process. Deleting E2f1, a downstream target of CDKs, provided temporary protection in Rd1 mice. Most importantly, genetic ablation of Bmi1 provided extensive photoreceptor survival and improvement of retinal function in Rd1 mice, mediated by a decrease in cell cycle markers and regulators independent of p16^Ink4a and p19^Arf. These data reveal that Bmi1 controls the cell cycle-related death process, highlighting this pathway as a promising therapeutic target for neuroprotection in retinal dystrophies.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574927

DOI: 10.1073/pnas.1108297110
PubMed: 23359713
PubMed Central: 3574927

Affiliations:

Canada, Pays-Bas, Suisse, Suède

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins</title>
<author><name sortKey="Zencak, Dusan" sort="Zencak, Dusan" uniqKey="Zencak D" first="Dusan" last="Zencak">Dusan Zencak</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Unit of Gene Therapy and Stem Cell Biology, Jules-Gonin Eye Hospital,<institution>University of Lausanne</institution>
, 1004 Lausanne,<country>Switzerland</country>
;</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schouwey, Karine" sort="Schouwey, Karine" uniqKey="Schouwey K" first="Karine" last="Schouwey">Karine Schouwey</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Unit of Gene Therapy and Stem Cell Biology, Jules-Gonin Eye Hospital,<institution>University of Lausanne</institution>
, 1004 Lausanne,<country>Switzerland</country>
;</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Danian" sort="Chen, Danian" uniqKey="Chen D" first="Danian" last="Chen">Danian Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Toronto Western Research Institute, University Health Network, Samuel Lunenfeld Research Institute,<institution>University of Toronto</institution>
, Toronto, ON,<country>Canada</country>
 M5T 2S8;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ekstrom, Per" sort="Ekstrom, Per" uniqKey="Ekstrom P" first="Per" last="Ekström">Per Ekström</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Division of Ophthalmology, Department of Clinical Sciences,<institution>Lund University</institution>
, SE-221 84 Lund,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tanger, Ellen" sort="Tanger, Ellen" uniqKey="Tanger E" first="Ellen" last="Tanger">Ellen Tanger</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Division of Molecular Genetics<institution>and The Centre of Biomedical Genetics</institution>
, 1066 CX, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bremner, Rod" sort="Bremner, Rod" uniqKey="Bremner R" first="Rod" last="Bremner">Rod Bremner</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Toronto Western Research Institute, University Health Network, Samuel Lunenfeld Research Institute,<institution>University of Toronto</institution>
, Toronto, ON,<country>Canada</country>
 M5T 2S8;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Lohuizen, Maarten" sort="Van Lohuizen, Maarten" uniqKey="Van Lohuizen M" first="Maarten" last="Van Lohuizen">Maarten Van Lohuizen</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Division of Molecular Genetics<institution>and The Centre of Biomedical Genetics</institution>
, 1066 CX, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arsenijevic, Yvan" sort="Arsenijevic, Yvan" uniqKey="Arsenijevic Y" first="Yvan" last="Arsenijevic">Yvan Arsenijevic</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Unit of Gene Therapy and Stem Cell Biology, Jules-Gonin Eye Hospital,<institution>University of Lausanne</institution>
, 1004 Lausanne,<country>Switzerland</country>
;</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23359713</idno>
<idno type="pmc">3574927</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574927</idno>
<idno type="RBID">PMC:3574927</idno>
<idno type="doi">10.1073/pnas.1108297110</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000664</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000664</idno>
<idno type="wicri:Area/Pmc/Curation">000664</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000664</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000587</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000587</idno>
<idno type="wicri:Area/Ncbi/Merge">001372</idno>
<idno type="wicri:Area/Ncbi/Curation">001372</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001372</idno>
<idno type="wicri:doubleKey">0027-8424:2013:Zencak D:retinal:degeneration:depends</idno>
<idno type="wicri:Area/Main/Merge">000C87</idno>
<idno type="wicri:Area/Main/Curation">000C80</idno>
<idno type="wicri:Area/Main/Exploration">000C80</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins</title>
<author><name sortKey="Zencak, Dusan" sort="Zencak, Dusan" uniqKey="Zencak D" first="Dusan" last="Zencak">Dusan Zencak</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Unit of Gene Therapy and Stem Cell Biology, Jules-Gonin Eye Hospital,<institution>University of Lausanne</institution>
, 1004 Lausanne,<country>Switzerland</country>
;</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schouwey, Karine" sort="Schouwey, Karine" uniqKey="Schouwey K" first="Karine" last="Schouwey">Karine Schouwey</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Unit of Gene Therapy and Stem Cell Biology, Jules-Gonin Eye Hospital,<institution>University of Lausanne</institution>
, 1004 Lausanne,<country>Switzerland</country>
;</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Danian" sort="Chen, Danian" uniqKey="Chen D" first="Danian" last="Chen">Danian Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Toronto Western Research Institute, University Health Network, Samuel Lunenfeld Research Institute,<institution>University of Toronto</institution>
, Toronto, ON,<country>Canada</country>
 M5T 2S8;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ekstrom, Per" sort="Ekstrom, Per" uniqKey="Ekstrom P" first="Per" last="Ekström">Per Ekström</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Division of Ophthalmology, Department of Clinical Sciences,<institution>Lund University</institution>
, SE-221 84 Lund,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tanger, Ellen" sort="Tanger, Ellen" uniqKey="Tanger E" first="Ellen" last="Tanger">Ellen Tanger</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Division of Molecular Genetics<institution>and The Centre of Biomedical Genetics</institution>
, 1066 CX, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bremner, Rod" sort="Bremner, Rod" uniqKey="Bremner R" first="Rod" last="Bremner">Rod Bremner</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Toronto Western Research Institute, University Health Network, Samuel Lunenfeld Research Institute,<institution>University of Toronto</institution>
, Toronto, ON,<country>Canada</country>
 M5T 2S8;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Lohuizen, Maarten" sort="Van Lohuizen, Maarten" uniqKey="Van Lohuizen M" first="Maarten" last="Van Lohuizen">Maarten Van Lohuizen</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Division of Molecular Genetics<institution>and The Centre of Biomedical Genetics</institution>
, 1066 CX, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arsenijevic, Yvan" sort="Arsenijevic, Yvan" uniqKey="Arsenijevic Y" first="Yvan" last="Arsenijevic">Yvan Arsenijevic</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Unit of Gene Therapy and Stem Cell Biology, Jules-Gonin Eye Hospital,<institution>University of Lausanne</institution>
, 1004 Lausanne,<country>Switzerland</country>
;</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="ISSN">0027-8424</idno>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The epigenetic regulator Bmi1 controls proliferation in many organs. Reexpression of cell cycle proteins such as cyclin-dependent kinases (CDKs) is a hallmark of neuronal apoptosis in neurodegenerative diseases. Here we address the potential role of Bmi1 as a key regulator of cell cycle proteins during neuronal apoptosis. We show that several cell cycle proteins are expressed in different models of retinal degeneration and required in the <italic>Rd1</italic>
 photoreceptor death process. Deleting E2f1, a downstream target of CDKs, provided temporary protection in <italic>Rd1</italic>
 mice. Most importantly, genetic ablation of <italic>Bmi1</italic>
 provided extensive photoreceptor survival and improvement of retinal function in <italic>Rd1</italic>
 mice, mediated by a decrease in cell cycle markers and regulators independent of p16<sup>Ink4a</sup>
 and p19<sup>Arf</sup>
. These data reveal that Bmi1 controls the cell cycle-related death process, highlighting this pathway as a promising therapeutic target for neuroprotection in retinal dystrophies.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>Pays-Bas</li>
<li>Suisse</li>
<li>Suède</li>
</country>
</list>
<tree><country name="Suisse"><noRegion><name sortKey="Zencak, Dusan" sort="Zencak, Dusan" uniqKey="Zencak D" first="Dusan" last="Zencak">Dusan Zencak</name>
</noRegion>
<name sortKey="Arsenijevic, Yvan" sort="Arsenijevic, Yvan" uniqKey="Arsenijevic Y" first="Yvan" last="Arsenijevic">Yvan Arsenijevic</name>
<name sortKey="Schouwey, Karine" sort="Schouwey, Karine" uniqKey="Schouwey K" first="Karine" last="Schouwey">Karine Schouwey</name>
</country>
<country name="Canada"><noRegion><name sortKey="Chen, Danian" sort="Chen, Danian" uniqKey="Chen D" first="Danian" last="Chen">Danian Chen</name>
</noRegion>
<name sortKey="Bremner, Rod" sort="Bremner, Rod" uniqKey="Bremner R" first="Rod" last="Bremner">Rod Bremner</name>
</country>
<country name="Suède"><noRegion><name sortKey="Ekstrom, Per" sort="Ekstrom, Per" uniqKey="Ekstrom P" first="Per" last="Ekström">Per Ekström</name>
</noRegion>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Tanger, Ellen" sort="Tanger, Ellen" uniqKey="Tanger E" first="Ellen" last="Tanger">Ellen Tanger</name>
</noRegion>
<name sortKey="Van Lohuizen, Maarten" sort="Van Lohuizen, Maarten" uniqKey="Van Lohuizen M" first="Maarten" last="Van Lohuizen">Maarten Van Lohuizen</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C80 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C80 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3574927
   |texte=   Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:23359713" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins

Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.